| Gene Information | |
|---|---|
| Gene Name | GNL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 549 |
| Protein Names | Guanine nucleotide-binding protein-like 3 (E2-induced gene 3 protein) (Novel nucleolar protein 47) (NNP47) (Nucleolar GTP-binding protein 3) (Nucleostemin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000163938 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BVP2 |
| Gene Card | GNL3 |
| Uniprot ID | Q9BVP2 |
| Pfam | PF08701; PF01926 |
| In ASD | no |
| Allosteric Prediction | no (-0.997641296) |
| Ortholog in Animals | Alpaca_ GNL3 ( ortholog_one2one ) Dog_ GNL3 ( ortholog_one2one ) GuineaPig_ GNL3 ( ortholog_one2one ) Macaque_ GNL3 ( ortholog_one2one ) Mouse_ Gnl3 ( ortholog_one2one ) Pig_ GNL3 ( ortholog_one2one ) Rat_ Gnl3 ( ortholog_one2one ) Rabbit_ GNL3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NOA1, LSG1, GNL2, GNL1, MTG1, GNL3L |
| Tissue | NA |
| Tissue Specificity | Increased levels in lung tissue in cancer patients. {ECO:0000269|PubMed:16012751}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002186(Rat);0.307556(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11177 rs2289247 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:12464630}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}. |
| Mouse PG classification | NA |
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