| Gene Information | |
|---|---|
| Gene Name | SLAM |
| Organism | Homo sapiens (Human) |
| Gene Length | 335 |
| Protein Names | Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13291 |
| Gene Card | SLAMF1 |
| Uniprot ID | Q13291 |
| Pfam | PF06214 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation (PubMed:7617038). Activated B-cells express isoform 1, isoform 3 and a cytoplasmic isoform (PubMed:9091591). Isoform 4 is expressed in B-cells, primary T-cells, dendritic cells and macrophages. Isoform 4 is expressed in tumors of the central nervous system (PubMed:25710480). {ECO:0000269|PubMed:25710480, ECO:0000269|PubMed:7617038, ECO:0000269|PubMed:9091591}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1D4T (X-ray 1.10A ) 1D4W (X-ray 1.80A ) 1I3Z (X-ray 2.15A ) 1KA6 (NMR - ) 1KA7 (NMR - ) 1M27 (X-ray 2.50A ) |
| DBSNP | rs2295612 rs1373814964 rs3796504 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11806999}; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999). {ECO:0000269|PubMed:11806999}.; [Isoform 3]: Secreted {ECO:0000305|PubMed:7617038}.; [Isoform 4]: Cell membrane {ECO:0000305|PubMed:25710480}. Note=Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers. {ECO:0000269|PubMed:25710480}. |
| Mouse PG classification | NA |
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