| Gene Information | |
|---|---|
| Gene Name | SLC7A14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 771 |
| Protein Names | Probable cationic amino acid transporter (Solute carrier family 7 member 14) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000013293 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q8TBB6 |
| Gene Card | SLC7A14 |
| Uniprot ID | Q8TBB6 |
| Pfam | PF13520; PF13906 |
| In ASD | no |
| Allosteric Prediction | no (-0.626412433) |
| Ortholog in Animals | Alpaca_ SLC7A14 ( ortholog_one2one ) GuineaPig_ SLC7A14 ( ortholog_one2one ) Macaque_ SLC7A14 ( ortholog_one2one ) Mouse_ Slc7a14 ( ortholog_one2one ) Pig_ SLC7A14 ( ortholog_one2one ) Rat_ Slc7a14 ( ortholog_one2one ) Rabbit_ SLC7A14 ( ortholog_one2one ) |
| Ohnologs | SLC7A4, SLC7A1 |
| Paralogs | SLC7A6, SLC7A10, SLC7A9, SLC7A8, SLC7A11, SLC7A13, SLC7A7, SLC7A3, SLC7A2, SLC7A4, SLC7A1, SLC7A5 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Expressed in skin fibroblasts. {ECO:0000269|PubMed:22787143}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs587777273 rs765054383 rs2276717 rs375705180 rs79668755 rs181011740 rs587777272 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:22787143, ECO:0000269|PubMed:24670872}; Multi-pass membrane protein {ECO:0000269|PubMed:22787143, ECO:0000269|PubMed:24670872}. Note=Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes. |
| Mouse PG classification | HPG |
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