| Gene Information | |
|---|---|
| Gene Name | PDE8B |
| Organism | Homo sapiens (Human) |
| Gene Length | 885 |
| Protein Names | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein) |
| Target Name | cyclic nucleotide phosphodiesterase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000113231 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95263 |
| Gene Card | PDE8B |
| Uniprot ID | O95263 |
| Pfam | PF13426; PF08629; PF00233 |
| In ASD | no |
| Allosteric Prediction | yes (0.996988116) |
| Ortholog in Animals | Alpaca_ PDE8B ( ortholog_one2one ) Dog_ PDE8B ( ortholog_one2one ) GuineaPig_ PDE8B ( ortholog_one2one ) Macaque_ PDE8B ( ortholog_one2one ) Mouse_ Pde8b ( ortholog_one2one ) Pig_ PDE8B ( ortholog_one2one ) Rat_ Pde8b ( ortholog_one2one ) |
| Ohnologs | PDE8A |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | adipose.tissue |
| Tissue Specificity | Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed. In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates. {ECO:0000269|PubMed:12372422, ECO:0000269|PubMed:12681444}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs121918360 |
| Subcellular location [CC] | NA |
| Mouse PG classification | LPG |
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