| Gene Information | |
|---|---|
| Gene Name | PDE6B |
| Organism | Homo sapiens (Human) |
| Gene Length | 854 |
| Protein Names | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35) |
| Target Name | cyclic nucleotide phosphodiesterase |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000133256 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P35913 |
| Gene Card | PDE6B |
| Uniprot ID | P35913 |
| Pfam | PF01590; PF00233 |
| In ASD | no |
| Allosteric Prediction | yes (0.683409467) |
| Ortholog in Animals | Dog_ PDE6B ( ortholog_one2one ) GuineaPig_ PDE6B ( ortholog_one2one ) Macaque_ PDE6B ( ortholog_one2one ) Mouse_ Pde6b ( ortholog_one2one ) Pig_ PDE6B ( ortholog_one2one ) Rat_ Pde6b ( ortholog_one2one ) |
| Ohnologs | PDE6C, PDE6A |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE4C |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs144590560 rs555600300 rs115775983 rs551545798 rs62295357 rs201584824 rs121918582 rs10902758 rs760766981 rs527236088 rs751859807 rs121918581 rs17849286 rs141563823 |
| Subcellular location [CC] | Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:20940301}. |
| Mouse PG classification | HPG |
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