| Gene Information | |
|---|---|
| Gene Name | PRKCG |
| Organism | Homo sapiens (Human) |
| Gene Length | 697 |
| Protein Names | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) |
| Target Name | protein kinase c gamma |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000126583 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P05129 |
| Gene Card | PRKCG |
| Uniprot ID | P05129 |
| Pfam | PF00130; PF00168; PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | yes (1.601866614) |
| Ortholog in Animals | Alpaca_ PRKCG ( ortholog_one2one ) Dog_ PRKCG ( ortholog_one2one ) GuineaPig_ PRKCG ( ortholog_one2one ) Macaque_ PRKCG ( ortholog_one2one ) Mouse_ Prkcg ( ortholog_one2one ) Pig_ PRKCG ( ortholog_one2one ) Rat_ Prkcg ( ortholog_one2one ) Rabbit_ PRKCG ( ortholog_one2one ) |
| Ohnologs | PRKCA, PRKCB |
| Paralogs | PKN3, PKN1, PRKCE, PRKCH, PRKCZ, PRKCI, PKN2, PRKCA, PRKCB |
| Tissue | brain, cerebral.cortex, amygdala, caudate.nucleus, cerebellum, hippocampus, nucleus.accumbens |
| Tissue Specificity | Expressed in Purkinje cells of the cerebellar cortex. {ECO:0000269|PubMed:12644968}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2E73 (NMR - ) 2UZP (X-ray 2.00A ) |
| DBSNP | rs386134159 rs121918511 rs121918512 rs121918513 rs752933837 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P63318}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:29053796}; Peripheral membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250|UniProtKB:P63318}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63319}. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250|UniProtKB:P63318}. |
| Mouse PG classification | LPG |
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