| Gene Information | |
|---|---|
| Gene Name | TRIM9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 710 |
| Protein Names | E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000100505 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9C026 |
| Gene Card | TRIM9 |
| Uniprot ID | Q9C026 |
| Pfam | PF00041; PF00622; PF00643 |
| In ASD | no |
| Allosteric Prediction | no (-0.307488387) |
| Ortholog in Animals | Alpaca_ TRIM9 ( ortholog_one2one ) Dog_ TRIM9 ( ortholog_one2one ) GuineaPig_ TRIM9 ( ortholog_one2one ) Macaque_ TRIM9 ( ortholog_one2one ) Mouse_ Trim9 ( ortholog_one2one ) Pig_ TRIM9 ( ortholog_one2one ) Rat_ Trim9 ( ortholog_one2one ) Rabbit_ TRIM9 ( ortholog_one2one ) |
| Ohnologs | TRIM67 |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM22, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39, TRIM67 |
| Tissue | brain, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies. {ECO:0000269|PubMed:20085810}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DB8 (NMR - ) 7B2S (X-ray 1.50A ) |
| DBSNP | rs2275462 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20085810}. Cell projection, dendrite {ECO:0000269|PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q91ZY8}. Synapse {ECO:0000250|UniProtKB:Q91ZY8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZY8}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). {ECO:0000250|UniProtKB:Q91ZY8, ECO:0000269|PubMed:20085810}. |
| Mouse PG classification | NA |
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