| Gene Information | |
|---|---|
| Gene Name | PDE4C |
| Organism | Homo sapiens (Human) |
| Gene Length | 712 |
| Protein Names | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21) |
| Target Name | cyclic nucleotide phosphodiesterase |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000105650 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q08493 |
| Gene Card | PDE4C |
| Uniprot ID | Q08493 |
| Pfam | PF18100; PF00233 |
| In ASD | no |
| Allosteric Prediction | yes (1.221720958) |
| Ortholog in Animals | Alpaca_ PDE4C ( ortholog_one2one ) Dog_ PDE4C ( ortholog_one2one ) GuineaPig_ PDE4C ( ortholog_one2one ) Macaque_ PDE4C ( ortholog_one2one ) Mouse_ Pde4c ( ortholog_one2one ) Pig_ PDE4C ( ortholog_one2one ) Rat_ Pde4c ( ortholog_one2one ) |
| Ohnologs | PDE4A, PDE4D, PDE4B |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B |
| Tissue | tongue |
| Tissue Specificity | Expressed in various tissues but not in cells of the immune system. {ECO:0000269|PubMed:7843419}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2QYM (X-ray 1.90A ) |
| DBSNP | rs10413646 rs34503849 rs2229228 rs11879710 |
| Subcellular location [CC] | Cell projection, cilium {ECO:0000250|UniProtKB:Q3UEI1}. |
| Mouse PG classification | NA |
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