Gene Information
Gene NamePDE3A
OrganismHomo sapiens (Human)
Gene Length1141
Protein NamescGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)
Target Namecyclic nucleotide phosphodiesterase
Target TypeNA
Gene Age950 ( ENSG00000172572 )
Evolutionary StageEukaryota
AlphaFoldDBQ14432
Gene CardPDE3A
Uniprot IDQ14432
PfamPF00233
In ASDno
Allosteric Predictionyes (1.081381928)
Ortholog in AnimalsAlpaca_ PDE3A ( ortholog_one2one )
Dog_ PDE3A ( ortholog_one2one )
GuineaPig_ PDE3A ( ortholog_one2one )
Macaque_ PDE3A ( ortholog_one2one )
Mouse_ Pde3a ( ortholog_one2one )
Pig_ PDE3A ( ortholog_one2one )
Rat_ Pde3a ( ortholog_one2one )
Rabbit_ PDE3A ( ortholog_one2one )
OhnologsPDE3B
ParalogsPDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE11A, PDE5A, PDE7B, PDE6B, PDE4C
Tissueheart, left.atrium, left.ventricle, mitral.valve, pulmonary.valve
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7EG0  (EM  3.40A  )  7EG1  (EM  3.20A  )  7EG4  (EM  3.20A  )  7KWE  (X-ray  2.00A  )  7L27  (X-ray  1.70A  )  7L28  (X-ray  2.20A  )  7L29  (X-ray  2.08A  )  7LRC  (EM  2.97A  )  7LRD  (EM  3.22A  ) 
DBSNP rs12305038  rs794726865  rs794726864  rs794726864  rs794726866  rs794726867  rs794726868 
Subcellular location [CC]Membrane {ECO:0000250|UniProtKB:Q9Z0X4};
Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:35104454}.
Mouse PG classificationLPG
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