| Gene Information | |
|---|---|
| Gene Name | PDE1C |
| Organism | Homo sapiens (Human) |
| Gene Length | 709 |
| Protein Names | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3) |
| Target Name | cyclic nucleotide phosphodiesterase |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000154678 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14123 |
| Gene Card | PDE1C |
| Uniprot ID | Q14123 |
| Pfam | PF00233; PF08499 |
| In ASD | no |
| Allosteric Prediction | yes (0.728723388) |
| Ortholog in Animals | Alpaca_ PDE1C ( ortholog_one2one ) Dog_ PDE1C ( ortholog_one2one ) GuineaPig_ PDE1C ( ortholog_one2one ) Macaque_ PDE1C ( ortholog_one2one ) Mouse_ Pde1c ( ortholog_one2one ) Pig_ PDE1C ( ortholog_one2one ) Rat_ Pde1c ( ortholog_one2one ) Rabbit_ PDE1C ( ortholog_one2one ) |
| Ohnologs | PDE1B, PDE1A |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE11A, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | cerebral.cortex, heart |
| Tissue Specificity | Isoform PDE1C2 is present in the heart and brain and, at lower levels in the lung, liver, kidney and skeletal muscle (PubMed:8557689). Isoform PDE1C1 is expressed in the heart and brain and, at lower levels in lung (PubMed:8557689). Also expressed at low levels in uterus and testis (PubMed:8557689). {ECO:0000269|PubMed:8557689}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs775633137 |
| Subcellular location [CC] | Lysosome {ECO:0000250|UniProtKB:Q64338}. |
| Mouse PG classification | NA |
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