| Gene Information | |
|---|---|
| Gene Name | PDE11A |
| Organism | Homo sapiens (Human) |
| Gene Length | 933 |
| Protein Names | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A) |
| Target Name | dual 3',5'-cyclic-amp and -gmp phosphodiesterase 11a |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000128655 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HCR9 |
| Gene Card | PDE11A |
| Uniprot ID | Q9HCR9 |
| Pfam | PF01590; PF00233 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999970304) |
| Ortholog in Animals | Alpaca_ PDE11A ( ortholog_one2one ) Dog_ PDE11A ( ortholog_one2one ) GuineaPig_ PDE11A ( ortholog_one2one ) Macaque_ PDE11A ( ortholog_one2one ) Mouse_ Pde11a ( ortholog_one2one ) Pig_ PDE11A ( ortholog_one2one ) Rat_ Cyct ( ortholog_one2one ) |
| Ohnologs | PDE5A |
| Paralogs | PDE8A, PDE4A, PDE4D, PDE4B, PDE6A, PDE2A, PDE6C, PDE8B, PDE1B, PDE9A, PDE10A, PDE1A, PDE7A, PDE3B, PDE1C, PDE5A, PDE3A, PDE7B, PDE6B, PDE4C |
| Tissue | pancreas, prostate |
| Tissue Specificity | Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:11121118, ECO:0000269|PubMed:15800651, ECO:0000269|PubMed:16079899, ECO:0000269|PubMed:16767104}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs75127279 rs61306957 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}. |
| Mouse PG classification | NA |
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