| Gene Information | |
|---|---|
| Gene Name | HTRA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 480 |
| Protein Names | Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (L56) (Serine protease 11) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000166033 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q92743 |
| Gene Card | HTRA1 |
| Uniprot ID | Q92743 |
| Pfam | PF00219; PF07648; PF17820; PF02163 |
| In ASD | yes |
| Allosteric Prediction | yes (0.339573239) |
| Ortholog in Animals | Alpaca_ HTRA1 ( ortholog_one2one ) Dog_ HTRA1 ( ortholog_one2one ) GuineaPig_ HTRA1 ( ortholog_one2one ) Macaque_ HTRA1 ( ortholog_one2one ) Mouse_ Htra1 ( ortholog_one2one ) Pig_ HTRA1 ( ortholog_one2one ) Rat_ Htra1 ( ortholog_one2one ) Rabbit_ HTRA1 ( ortholog_one2one ) |
| Ohnologs | HTRA2, HTRA4, HTRA3 |
| Paralogs | HTRA2, HTRA4, HTRA3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:16377621, ECO:0000269|PubMed:9852107}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JOA (NMR - ) 2YTW (NMR - ) 3NUM (X-ray 2.75A ) 3NWU (X-ray 3.20A ) 3NZI (X-ray 2.75A ) 3TJN (X-ray 3.00A ) 3TJO (X-ray 2.30A ) 3TJQ (X-ray 2.00A ) 6Z0E (X-ray 2.60A ) 6Z0X (X-ray 3.10A ) 6Z0Y (X-ray 2.20A ) 7SJN (EM 3.40A ) 7SJO (EM 3.30A ) |
| DBSNP | rs369149111 rs864622781 rs781563777 rs113993968 rs864622782 rs113993969 rs772225907 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21297635}. Secreted {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:9852107}. Cytoplasm, cytosol {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:20671064}. Note=Predominantly secreted (PubMed:15208355). Also found associated with the plasma membrane (PubMed:21297635). {ECO:0000269|PubMed:15208355, ECO:0000269|PubMed:21297635}. |
| Mouse PG classification | NA |
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