| Gene Information | |
|---|---|
| Gene Name | WTIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 430 |
| Protein Names | Wilms tumor protein 1-interacting protein (WT1-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000142279 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | A6NIX2 |
| Gene Card | WTIP |
| Uniprot ID | A6NIX2 |
| Pfam | PF00412 |
| In ASD | no |
| Allosteric Prediction | no (-0.354800911) |
| Ortholog in Animals | Alpaca_ WTIP ( ortholog_one2one ) Dog_ WTIP ( ortholog_one2one ) GuineaPig_ WTIP ( ortholog_one2one ) Macaque_ WTIP ( ortholog_one2one ) Mouse_ Wtip ( ortholog_one2one ) Pig_ WTIP ( ortholog_one2one ) Rat_ Wtip ( ortholog_one2one ) |
| Ohnologs | AJUBA |
| Paralogs | LIMD1, AJUBA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, adherens junction. Nucleus {ECO:0000250}. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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