| Gene Information | |
|---|---|
| Gene Name | ARMC9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 818 |
| Protein Names | LisH domain-containing protein ARMC9 (Armadillo repeat-containing protein 9) (Melanoma/melanocyte-specific tumor antigen KU-MEL-1) (NS21) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000135931 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z3E5 |
| Gene Card | ARMC9 |
| Uniprot ID | Q7Z3E5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.3144637) |
| Ortholog in Animals | Alpaca_ ARMC9 ( ortholog_one2one ) Dog_ ARMC9 ( ortholog_one2one ) GuineaPig_ ARMC9 ( ortholog_one2one ) Macaque_ ARMC9 ( ortholog_one2one ) Mouse_ Armc9 ( ortholog_one2one ) Pig_ ARMC9 ( ortholog_one2one ) Rat_ Armc9 ( ortholog_one2one ) Rabbit_ ARMC9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis. {ECO:0000269|PubMed:11691810}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs750247691 rs11558175 rs1626450 rs16827883 rs3752780 rs759799287 rs753432312 rs780265931 rs1114167449 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28625504}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28625504}. Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity). Localizes to the daughter centriole of the primary cilium in RPE1 cells (PubMed:28625504). {ECO:0000250|UniProtKB:Q9D2I5, ECO:0000269|PubMed:28625504}. |
| Mouse PG classification | NA |
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