| Gene Information | |
|---|---|
| Gene Name | IRF |
| Organism | Homo sapiens (Human) |
| Gene Length | 353 |
| Protein Names | E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q969Q1 |
| Gene Card | TRIM63 |
| Uniprot ID | Q969Q1 |
| Pfam | PF00643; PF13445 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. {ECO:0000269|PubMed:11243782, ECO:0000269|PubMed:11283016, ECO:0000269|PubMed:11679633, ECO:0000269|PubMed:12107412}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2D8U (NMR - ) 3DDT (X-ray 1.90A ) 4M3L (X-ray 2.10A ) |
| DBSNP | rs762015648 rs758754060 rs529429430 rs1338320582 rs142601731 rs376414719 rs2275950 rs201397530 rs202001619 |
| Subcellular location [CC] | Cytoplasm. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}. |
| Mouse PG classification | NA |
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