| Gene Information | |
|---|---|
| Gene Name | PCSK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1860 |
| Protein Names | Proprotein convertase subtilisin/kexin type 5 (EC 3.4.21.-) (Proprotein convertase 5) (PC5) (Proprotein convertase 6) (PC6) (hPC6) (Subtilisin/kexin-like protease PC5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000099139 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q92824 |
| Gene Card | PCSK5 |
| Uniprot ID | Q92824 |
| Pfam | PF14843; PF01483; PF00082; PF16470 |
| In ASD | no |
| Allosteric Prediction | no (-0.26848453) |
| Ortholog in Animals | Alpaca_ PCSK5 ( ortholog_one2one ) Dog_ PCSK5 ( ortholog_one2one ) GuineaPig_ PCSK5 ( ortholog_one2one ) Macaque_ PCSK5 ( ortholog_one2one ) Mouse_ Pcsk5 ( ortholog_one2one ) Pig_ PCSK5 ( ortholog_one2one ) Rat_ Pcsk5 ( ortholog_one2one ) Rabbit_ PCSK5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PCSK1, TPP2, PCSK6, MBTPS1, PCSK7, PCSK9, PCSK4, FURIN, PCSK2 |
| Tissue | small.intestine |
| Tissue Specificity | Expressed in T-lymphocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform PC6A]: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein. Note=Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. {ECO:0000250}. |
| Mouse PG classification | NA |
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