| Gene Information | |
|---|---|
| Gene Name | PGAM5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 289 |
| Protein Names | Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC 3.1.3.16) (Bcl-XL-binding protein v68) (Phosphoglycerate mutase family member 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000247077 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96HS1 |
| Gene Card | PGAM5 |
| Uniprot ID | Q96HS1 |
| Pfam | PF00300 |
| In ASD | no |
| Allosteric Prediction | no (-0.263996005) |
| Ortholog in Animals | Alpaca_ PGAM5 ( ortholog_one2one ) Dog_ PGAM5 ( ortholog_one2one ) GuineaPig_ PGAM5 ( ortholog_one2one ) Macaque_ PGAM5 ( ortholog_one2one ) Mouse_ Pgam5 ( ortholog_one2one ) Pig_ PGAM5 ( ortholog_one2one ) Rat_ Pgam5 ( ortholog_one2one ) Rabbit_ PGAM5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3MXO (X-ray 1.70A ) 3O0T (X-ray 1.90A ) 5MUF (X-ray 3.10A ) 6CNI (X-ray 1.70A ) 6CNL (X-ray 2.60A ) 7QAL (NMR - ) 7QAM (NMR - ) 7QAO (NMR - ) 7QAP (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion outer membrane {ECO:0000269|PubMed:18387606}; Single-pass membrane protein {ECO:0000269|PubMed:18387606}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus. |
| Mouse PG classification | NA |
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