| Gene Information | |
|---|---|
| Gene Name | PCSK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 753 |
| Protein Names | Neuroendocrine convertase 1 (NEC 1) (EC 3.4.21.93) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) |
| Target Name | neuroendocrine convertase 1 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000175426 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P29120 |
| Gene Card | PCSK1 |
| Uniprot ID | P29120 |
| Pfam | PF01483; PF00082; PF12177; PF16470 |
| In ASD | no |
| Allosteric Prediction | yes (0.78363169) |
| Ortholog in Animals | Alpaca_ PCSK1 ( ortholog_one2one ) Dog_ PCSK1 ( ortholog_one2one ) GuineaPig_ PCSK1 ( ortholog_one2one ) Macaque_ PCSK1 ( ortholog_one2one ) Mouse_ Pcsk1 ( ortholog_one2one ) Pig_ PCSK1 ( ortholog_one2one ) Rat_ Pcsk1 ( ortholog_one2one ) Rabbit_ PCSK1 ( ortholog_one2one ) |
| Ohnologs | PCSK4, PCSK6, FURIN |
| Paralogs | TPP2, PCSK6, MBTPS1, PCSK7, PCSK5, PCSK9, PCSK4, FURIN, PCSK2 |
| Tissue | brain, cerebral.cortex, brain.meninx, middle.frontal.gyrus, occipital.lobe, olfactory.apparatus, pineal.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1799904 rs137852823 rs6232 rs137852824 rs137852821 rs6234 rs6235 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |