Gene Information
Gene NamePCP2
OrganismHomo sapiens (Human)
Gene Length1446
Protein NamesReceptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000174788 )
Evolutionary StageMammalia
AlphaFoldDBQ92729
Gene CardPTPRU
Uniprot IDQ92729
PfamPF00041; PF00629; PF00102
In ASDno
Allosteric Predictionno (-0.333219381)
Ortholog in AnimalsAlpaca_ PCP2 ( ortholog_one2one )
Dog_ PCP2 ( ortholog_one2one )
GuineaPig_ PCP2 ( ortholog_one2one )
Macaque_ PCP2 ( ortholog_one2one )
Mouse_ Pcp2 ( ortholog_one2one )
Pig_ PCP2 ( ortholog_one2one )
Rat_ Pcp2 ( ortholog_one2one )
Rabbit_ PCP2 ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissuetestis
Tissue SpecificityHigh levels in brain, pancreas, and skeletal muscle;
less in colon, kidney, liver, stomach, and uterus;
not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells. {ECO:0000269|PubMed:8700514, ECO:0000269|PubMed:8870675, ECO:0000269|PubMed:9070223, ECO:0000269|PubMed:9434160}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6SUB  (X-ray  1.72A  )  6SUC  (X-ray  1.97A  ) 
DBSNP rs35332573  rs35745442  rs558954146  rs763868325  rs2235937 
Subcellular location [CC]Cell junction {ECO:0000269|PubMed:8700514}. Cell membrane {ECO:0000269|PubMed:8700514};
Single-pass type I membrane protein {ECO:0000269|PubMed:8700514}.
Mouse PG classificationNA
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