| Gene Information | |
|---|---|
| Gene Name | PCM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 605 |
| Protein Names | Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000078674 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9UIS9 |
| Gene Card | MBD1 |
| Uniprot ID | Q9UIS9 |
| Pfam | PF01429; PF02008 |
| In ASD | no |
| Allosteric Prediction | no (-0.353739955) |
| Ortholog in Animals | Alpaca_ PCM1 ( ortholog_one2one ) Dog_ PCM1 ( ortholog_one2one ) GuineaPig_ PCM1 ( ortholog_one2one ) Macaque_ PCM1 ( ortholog_one2one ) Mouse_ Pcm1 ( ortholog_one2one ) Pig_ PCM1 ( ortholog_one2one ) Rat_ Pcm1 ( ortholog_one2one ) Rabbit_ PCM1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9207790}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D9N (NMR - ) 1IG4 (NMR - ) 4D4W (NMR - ) 5W9Q (X-ray 1.80A ) 6D1T (X-ray 2.25A ) |
| DBSNP | rs125555 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14610093}. Nucleus matrix {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624}. Nucleus speckle {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624}. Chromosome {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12711603, ECO:0000269|PubMed:14555760}. Note=Nuclear, in a punctate pattern (PubMed:12711603). Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes (PubMed:10648624, PubMed:10454587). {ECO:0000269|PubMed:10454587, ECO:0000269|PubMed:10648624, ECO:0000269|PubMed:12711603}. |
| Mouse PG classification | NA |
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