| Gene Information | |
|---|---|
| Gene Name | PCLAF |
| Organism | Homo sapiens (Human) |
| Gene Length | 111 |
| Protein Names | PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000166803 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15004 |
| Gene Card | PCLAF |
| Uniprot ID | Q15004 |
| Pfam | PF15715 |
| In ASD | no |
| Allosteric Prediction | no (-0.718121565) |
| Ortholog in Animals | Alpaca_ PCLAF ( ortholog_one2one ) Dog_ PCLAF ( ortholog_one2one ) GuineaPig_ PCLAF ( ortholog_one2one ) Macaque_ PCLAF ( ortholog_one2one ) Mouse_ Pclaf ( ortholog_one2one ) Pig_ PCLAF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | appendix, bone.marrow, colon, dura.mater, heart, spleen, tongue |
| Tissue Specificity | Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-small-cell lung cancer lines. {ECO:0000269|PubMed:11313979, ECO:0000269|PubMed:15789362, ECO:0000269|PubMed:22096502}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4D2G (X-ray 2.65A ) 6EHT (X-ray 3.20A ) 6GWS (X-ray 2.90A ) 6IIW (X-ray 1.70A ) |
| DBSNP | rs11554313 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11313979, ECO:0000269|PubMed:16288740, ECO:0000269|PubMed:21673012, ECO:0000269|PubMed:23000965}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21673012}. Note=Following DNA damage, localizes to DNA damage sites (PubMed:21628590). Colocalizes with centrosomes in perinuclear region (PubMed:21673012). |
| Mouse PG classification | NA |
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