| Gene Information | |
|---|---|
| Gene Name | PCL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 580 |
| Protein Names | PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q5T6S3 |
| Gene Card | PHF19 |
| Uniprot ID | Q5T6S3 |
| Pfam | PF14061; PF00628; PF18104 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma and in glioma cell lines. {ECO:0000269|PubMed:15563832}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E5Q (NMR - ) 4BD3 (NMR - ) 6NQ3 (X-ray 2.89A ) 6WAU (X-ray 1.75A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:31959557}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:31959557}. |
| Mouse PG classification | NA |
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