| Gene Information | |
|---|---|
| Gene Name | GABRA4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 554 |
| Protein Names | Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4) |
| Target Name | gaba(a) receptor |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000109158 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48169 |
| Gene Card | GABRA4 |
| Uniprot ID | P48169 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (1.027616674) |
| Ortholog in Animals | Alpaca_ GABRA4 ( ortholog_one2one ) Dog_ GABRA4 ( ortholog_one2one ) GuineaPig_ GABRA4 ( ortholog_one2one ) Macaque_ GABRA4 ( ortholog_one2one ) Mouse_ Gabra4 ( ortholog_one2one ) Pig_ GABRA4 ( ortholog_one2one ) Rat_ Gabra4 ( ortholog_one2one ) Rabbit_ GABRA4 ( ortholog_one2one ) |
| Ohnologs | GABRA3, GABRA1, GABRE, GABRG2, GABRA6, GABRG3, GABRA5 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | brain, heart, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7QN5 (EM 2.50A ) 7QN7 (EM 3.00A ) 7QN9 (EM 2.90A ) 7QNA (EM 3.00A ) 7QNC (EM 2.90A ) |
| DBSNP | rs16859837 rs2229940 |
| Subcellular location [CC] | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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