| Gene Information | |
|---|---|
| Gene Name | PRKCI |
| Organism | Homo sapiens (Human) |
| Gene Length | 596 |
| Protein Names | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) |
| Target Name | protein kinase c |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000163558 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P41743 |
| Gene Card | PRKCI |
| Uniprot ID | P41743 |
| Pfam | PF00130; PF00564; PF00069; PF00433 |
| In ASD | yes |
| Allosteric Prediction | yes (1.073561122) |
| Ortholog in Animals | Alpaca_ PRKCI ( ortholog_one2one ) Dog_ PRKCI ( ortholog_one2one ) GuineaPig_ PRKCI ( ortholog_one2one ) Macaque_ PRKCI ( ortholog_one2one ) Mouse_ Prkci ( ortholog_one2one ) Pig_ PRKCI ( ortholog_one2one ) Rat_ Prkci ( ortholog_one2one ) Rabbit_ PRKCI ( ortholog_one2one ) |
| Ohnologs | PRKCZ |
| Paralogs | PKN3, PKN1, PRKCE, PRKCH, PKN2, PRKCG, PRKCA, PRKCB, PRKCZ |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in lung and brain, but also expressed at lower levels in many tissues including pancreatic islets. Highly expressed in non-small cell lung cancers. {ECO:0000269|PubMed:15994303, ECO:0000269|PubMed:7607695, ECO:0000269|PubMed:8226978}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002272(Rat);0.058824(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1VD2 (NMR - ) 1WMH (X-ray 1.50A ) 1ZRZ (X-ray 3.00A ) 3A8W (X-ray 2.10A ) 3A8X (X-ray 2.00A ) 3ZH8 (X-ray 2.74A ) 5LI1 (X-ray 2.00A ) 5LI9 (X-ray 1.79A ) 5LIH (X-ray 3.25A ) 6ILZ (X-ray 3.26A ) |
| DBSNP | rs56154494 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:9566925}. Membrane {ECO:0000269|PubMed:16452474}. Endosome {ECO:0000269|PubMed:9566925}. Nucleus {ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:15695176}. Note=Transported into the endosome through interaction with SQSTM1/p62. After phosphorylation by SRC, transported into the nucleus through interaction with KPNB1. Colocalizes with CDK7 in the cytoplasm and nucleus. Transported to vesicular tubular clusters (VTCs) through interaction with RAB2A. {ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:9566925}. |
| Mouse PG classification | NA |
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