| Gene Information | |
|---|---|
| Gene Name | NNMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 264 |
| Protein Names | Nicotinamide N-methyltransferase (EC 2.1.1.1) |
| Target Name | nicotinamide n-methyltransferase |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000166741 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P40261 |
| Gene Card | NNMT |
| Uniprot ID | P40261 |
| Pfam | PF01234 |
| In ASD | no |
| Allosteric Prediction | yes (0.303307802) |
| Ortholog in Animals | Alpaca_ NNMT ( ortholog_one2one ) Dog_ NNMT ( ortholog_one2one ) GuineaPig_ NNMT ( ortholog_one2one ) Macaque_ NNMT ( ortholog_one2one ) Mouse_ Nnmt ( ortholog_one2one ) Pig_ NNMT ( ortholog_one2one ) Rat_ Nnmt ( ortholog_one2one ) |
| Ohnologs | PNMT |
| Paralogs | INMT, PNMT |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas. {ECO:0000269|PubMed:8182091}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IIP (X-ray 2.05A ) 3ROD (X-ray 2.72A ) 5YJF (X-ray 2.49A ) 6CHH (X-ray 2.30A ) 6ORR (X-ray 2.25A ) 6PVE (X-ray 2.30A ) 6PVS (X-ray 2.58A ) 7BKG (X-ray 2.33A ) 7BLE (X-ray 2.81A ) 7EGU (X-ray 1.90A ) 7EHZ (X-ray 2.50A ) 7EI2 (X-ray 2.08A ) 7ET7 (X-ray 2.61A ) 7EU5 (X-ray 2.73A ) 7NBJ (X-ray 2.27A ) 7NBM (X-ray 2.69A ) 7NBQ (X-ray 2.48A ) 7WMC (X-ray 2.55A ) 7WMT (X-ray 1.77A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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