| Gene Information | |
|---|---|
| Gene Name | PIK4CB |
| Organism | Homo sapiens (Human) |
| Gene Length | 816 |
| Protein Names | Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UBF8 |
| Gene Card | PI4KB |
| Uniprot ID | Q9UBF8 |
| Pfam | PF00454 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. {ECO:0000269|PubMed:9020160, ECO:0000269|PubMed:9405935, ECO:0000269|PubMed:9405938}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2N73 (NMR - ) 4D0L (X-ray 2.94A ) 4D0M (X-ray 6.00A ) 4WAE (X-ray 3.32A ) 4WAG (X-ray 3.41A ) 5C46 (X-ray 2.65A ) 5C4G (X-ray 3.20A ) 5EUQ (X-ray 3.20A ) 5FBL (X-ray 3.37A ) 5FBQ (X-ray 3.79A ) 5FBR (X-ray 3.28A ) 5FBV (X-ray 3.29A ) 5FBW (X-ray 3.49A ) 5LX2 (X-ray 2.58A ) 5NAS (X-ray 2.08A ) 6GL3 (X-ray 2.77A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus {ECO:0000269|PubMed:22124328}. Golgi apparatus membrane {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the recruitment (PubMed:28289207). {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}. |
| Mouse PG classification | NA |
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