| Gene Information | |
|---|---|
| Gene Name | PLCL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1095 |
| Protein Names | Inactive phospholipase C-like protein 1 (PLC-L1) (Phospholipase C-deleted in lung carcinoma) (Phospholipase C-related but catalytically inactive protein) (PRIP) |
| Target Name | inactive phospholipase c-like protein 1 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000115896 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15111 |
| Gene Card | PLCL1 |
| Uniprot ID | Q15111 |
| Pfam | PF00168; PF09279; PF16457; PF00388; PF00387 |
| In ASD | no |
| Allosteric Prediction | yes (0.283349564) |
| Ortholog in Animals | Alpaca_ PLCL1 ( ortholog_one2one ) Dog_ PLCL1 ( ortholog_one2one ) GuineaPig_ PLCL1 ( ortholog_one2one ) Macaque_ PLCL1 ( ortholog_one2one ) Mouse_ Plcl1 ( ortholog_one2one ) Pig_ PLCL1 ( ortholog_one2one ) Rat_ Plcl1 ( ortholog_one2one ) Rabbit_ PLCL1 ( ortholog_one2one ) |
| Ohnologs | PLCL2 |
| Paralogs | PLCG2, PLCD3, PLCB3, PLCE1, PLCG1, PLCB1, PLCD4, PLCD1, PLCB2, PLCB4, PLCL2, PLCH1, PLCZ1, PLCH2 |
| Tissue | NA |
| Tissue Specificity | Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. {ECO:0000269|PubMed:16952428, ECO:0000269|PubMed:7633416}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs45506698 rs45506696 rs45596936 rs1064213 rs6741084 rs45452996 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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