Gene Information
Gene NameSPAG5
OrganismHomo sapiens (Human)
Gene Length1193
Protein NamesSperm-associated antigen 5 (Astrin) (Deepest) (Mitotic spindle-associated protein p126) (MAP126)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000076382 )
Evolutionary StageMammalia
AlphaFoldDBQ96R06
Gene CardSPAG5
Uniprot IDQ96R06
PfamNA
In ASDno
Allosteric Predictionno (-1.000940461)
Ortholog in AnimalsAlpaca_ SPAG5 ( ortholog_one2one )
Dog_ RSKR ( ortholog_one2one )
GuineaPig_ SPAG5 ( ortholog_one2one )
Macaque_ SPAG5 ( ortholog_one2one )
Mouse_ Spag5 ( ortholog_one2one )
Pig_ SPAG5 ( ortholog_one2one )
Rat_ Spag5 ( ortholog_one2one )
Rabbit_ SPAG5 ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissuetestis
Tissue SpecificityHighly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon. {ECO:0000269|PubMed:11549262}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:27462074}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:27462074}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:27462074}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:27462074}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:27462074}. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic granule. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26297806}. Note=Colocalizes with PCM1 at centriolar satellites throughout the cell cycle (PubMed:26297806). In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase (PubMed:27462074). Efficient targeting to the mitotic spindle may depend upon phosphorylation by GSK3B. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (By similarity). In non-mitotic non-stressed cells, shows a microtubuli pattern. In arsenite-stressed cells, accumulates in stress granules. {ECO:0000250, ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074}.
Mouse PG classificationNA
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