Gene Information
Gene NameSORBS1
OrganismHomo sapiens (Human)
Gene Length1292
Protein NamesSorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000095637 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9BX66
Gene CardSORBS1
Uniprot IDQ9BX66
PfamPF00018; PF07653; PF14604; PF02208
In ASDno
Allosteric Predictionyes (0.033215975)
Ortholog in AnimalsAlpaca_ SORBS1 ( ortholog_one2one )
Dog_ SORBS1 ( ortholog_one2one )
GuineaPig_ SORBS1 ( ortholog_one2one )
Macaque_ SORBS1 ( ortholog_one2one )
Mouse_ Sorbs1 ( ortholog_one2one )
Pig_ SORBS1 ( ortholog_one2one )
Rat_ Sorbs1 ( ortholog_one2one )
Rabbit_ SORBS1 ( ortholog_one2one )
OhnologsNA
ParalogsSH3GL3, SORBS2, SH3GLB1, SORBS3, SH3GLB2, NCF4, SH3RF3, SH3RF2, SH3GL1, SH3RF1, SH3D19, SH3GL2
TissueNA
Tissue SpecificityDetected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:11374898, ECO:0000269|PubMed:17462669}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DL3  (NMR  -  )  2ECZ  (NMR  -  )  2LJ0  (NMR  -  )  2LJ1  (NMR  -  )  2MOX  (NMR  -  )  2O2W  (X-ray  2.27A  )  2O31  (X-ray  1.50A  )  2O9S  (X-ray  0.83A  )  2O9V  (X-ray  1.63A  )  4LN2  (X-ray  1.00A  )  4LNP  (X-ray  1.41A  ) 
DBSNP rs943542  rs757431022  rs7081076  rs2281939  rs35808802 
Subcellular location [CC]Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}.
Mouse PG classificationNA
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