| Gene Information | |
|---|---|
| Gene Name | PCDH12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1184 |
| Protein Names | Protocadherin-12 (Vascular cadherin-2) (Vascular endothelial cadherin-2) (VE-cad-2) (VE-cadherin-2) [Cleaved into: Protocadherin-12, secreted form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000113555 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPG4 |
| Gene Card | PCDH12 |
| Uniprot ID | Q9NPG4 |
| Pfam | PF00028; PF08266 |
| In ASD | no |
| Allosteric Prediction | no (-1.000096647) |
| Ortholog in Animals | Alpaca_ PCDH12 ( ortholog_one2one ) Dog_ PCDH12 ( ortholog_one2one ) GuineaPig_ PCDH12 ( ortholog_one2one ) Macaque_ PCDH12 ( ortholog_one2one ) Mouse_ Pcdh12 ( ortholog_one2one ) Pig_ PCDH12 ( ortholog_one2one ) Rat_ Pcdh12 ( ortholog_one2one ) Rabbit_ PCDH12 ( ortholog_one2one ) |
| Ohnologs | PCDH17, PCDH8, PCDH19, PCDH10, PCDH18 |
| Paralogs | CDHR4, PCDHGB3, PCDHGB1, PCDHGA3, PCDH17, PCDHA13, PCDHGA8, PCDHB16, PCDHA11, PCDHGB6, PCDHGC5, PCDHGC4, PCDHB9, PCDHB10, PCDHA12, PCDHA10, PCDHA9, PCDHA7, PCDHA5, PCDH10, PCDHB6, PCDH15, PCDHB13, PCDHB2, PCDHGA7, PCDHGC3, PCDHB1, PCDHGA5, PCDHA3, PCDHAC2, PCDHB4, PCDHA4, PCDHB5, PCDHGA10, PCDHGB2, PCDH19, PCDH8, PCDH18, PCDHGA1, PCDHGA11, PCDHGA12, PCDHGA2, PCDHB7, PCDHGB7, PCDHGA9, PCDHGB4, PCDHGB5, PCDHA8, PCDHA6, PCDHA2, PCDHB12, PCDHB11, PCDHB14, PCDHB8, PCDHGA4, PCDHB15, CDH16, PCDHA1, PCDHB3, PCDHAC1, PCDHGA6 |
| Tissue | NA |
| Tissue Specificity | Expressed in highly vascularized tissues including the heart and placenta, but most tissues contain a low level of expression (PubMed:11063261). Prominent expression in the spleen (PubMed:11063261). Present in villous and extravillous trophoblast (at protein level) (PubMed:21402705). {ECO:0000269|PubMed:11063261, ECO:0000269|PubMed:21402705}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs200451693 rs759794990 rs146725009 rs164075 rs164515 rs779814208 |
| Subcellular location [CC] | [Protocadherin-12]: Cell membrane {ECO:0000269|PubMed:21402705}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000250|UniProtKB:O55134}.; [Protocadherin-12, secreted form]: Secreted {ECO:0000269|PubMed:21402705}. Note=The secreted form is produced following cleavage by ADAM10. {ECO:0000269|PubMed:21402705}. |
| Mouse PG classification | NA |
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