Gene Information
Gene NamePCAF
OrganismHomo sapiens (Human)
Gene Length832
Protein NamesHistone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ92831
Gene CardKAT2B
Uniprot IDQ92831
PfamPF00583; PF00439; PF06466
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityUbiquitously expressed but most abundant in heart and skeletal muscle. Also expressed in the skin, in keratinocytes (at protein level) (PubMed:20940255). {ECO:0000269|PubMed:20940255, ECO:0000269|PubMed:8684459}.
Pharmacological Animal Models0.012808(Chimpanzee);0.151945(Mouse);NULL(Rat);0.036190(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CM0  (X-ray  2.30A  )  1JM4  (NMR  -  )  1N72  (NMR  -  )  1WUG  (NMR  -  )  1WUM  (NMR  -  )  1ZS5  (NMR  -  )  2RNW  (NMR  -  )  2RNX  (NMR  -  )  3GG3  (X-ray  2.25A  )  4NSQ  (X-ray  2.31A  )  5FDZ  (X-ray  2.40A  )  5FE0  (X-ray  2.30A  )  5FE1  (X-ray  2.22A  )  5FE2  (X-ray  2.25A  )  5FE3  (X-ray  2.12A  )  5FE4  (X-ray  2.15A  )  5FE5  (X-ray  2.12A  )  5FE6  (X-ray  1.77A  )  5FE7  (X-ray  2.08A  )  5FE8  (X-ray  2.10A  )  5FE9  (X-ray  2.35A  )  5LVQ  (X-ray  2.05A  )  5LVR  (X-ray  2.05A  )  5MKX  (X-ray  1.68A  )  6J3O  (X-ray  2.11A  ) 
DBSNP rs17006625 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:20940255, ECO:0000269|PubMed:29174768}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29174768}. Cytoplasm {ECO:0000269|PubMed:20940255}. Note=Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255). {ECO:0000269|PubMed:20940255, ECO:0000269|PubMed:29174768}.
Mouse PG classificationNA
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