Gene Information
Gene NamePC1
OrganismHomo sapiens (Human)
Gene Length925
Protein NamesEctonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP22413
Gene CardENPP1
Uniprot IDP22413
PfamPF01223; PF01663; PF01033
In ASDyes
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityExpressed in plasma cells and also in a number of non-lymphoid tissues, including the distal convoluted tubule of the kidney, chondrocytes and epididymis (PubMed:9344668). Expressed in melanocytes but not in keratinocytes (PubMed:28964717). {ECO:0000269|PubMed:28964717, ECO:0000269|PubMed:9344668}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2YS0  (NMR  -  )  6WET  (X-ray  2.60A  )  6WEU  (X-ray  2.65A  )  6WEV  (X-ray  2.90A  )  6WEW  (X-ray  2.73A  )  6WFJ  (X-ray  2.50A  ) 
DBSNP rs397518477  rs397518476  rs1044498  rs397518475  rs2273411  rs763457176  rs760786509  rs1231182870  rs754659608  rs121908248  rs17847050  rs143771474  rs190947144  rs374270497  rs121918025  rs764735802  rs121918026  rs765071179  rs148462924  rs373044722  rs1243920034  rs387906673  rs140248167  rs121918024  rs777367269  rs79079368  rs143393727  rs115371819  rs28933977  rs147346173  rs1805138  rs370184526  rs367759638  rs8192683  rs184483616  rs121908249 
Subcellular location [CC][Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane {ECO:0000269|PubMed:15072822, ECO:0000269|PubMed:27467858, ECO:0000269|PubMed:8001561};
Single-pass type II membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:11598187};
Single-pass type II membrane protein. Note=Targeted to the basolateral membrane in polarized epithelial cells and in hepatocytes, and to matrix vesicles in osteoblasts (PubMed:11598187). In bile duct cells and cancer cells, located to the apical cytoplasmic side (PubMed:11598187). {ECO:0000269|PubMed:11598187}.;
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted {ECO:0000250|UniProtKB:P06802}. Note=Secreted following proteolytic cleavage. {ECO:0000250|UniProtKB:P06802}.
Mouse PG classificationNA
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