| Gene Information | |
|---|---|
| Gene Name | PBX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 430 |
| Protein Names | Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000185630 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P40424 |
| Gene Card | PBX1 |
| Uniprot ID | P40424 |
| Pfam | PF00046; PF03792 |
| In ASD | yes |
| Allosteric Prediction | yes (0.353034938) |
| Ortholog in Animals | Alpaca_ PBX1 ( ortholog_one2one ) Dog_ PBX1 ( ortholog_one2one ) GuineaPig_ PBX1 ( ortholog_one2one ) Macaque_ PBX1 ( ortholog_one2one ) Mouse_ Pbx1 ( ortholog_one2one ) Rat_ Pbx1 ( ortholog_one2one ) Rabbit_ PBX1 ( ortholog_one2one ) |
| Ohnologs | PBX3, PBX2 |
| Paralogs | PKNOX2, PBX4, MEIS1, TGIF2LX, TGIF2LY, PKNOX1, MEIS2, TGIF2, PBX2, MEIS3, TGIF1, PBX3 |
| Tissue | NA |
| Tissue Specificity | Expressed in the kidney. Expressed in the endothelial cells of the glomeruli and interstitium (at protein level) (PubMed:28270404). Expressed in all tissues except in cells of the B and T lineage. Expressed strongly in kidney and brain (PubMed:28270404). {ECO:0000269|PubMed:28270404}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B72 (X-ray 2.35A ) 1PUF (X-ray 1.90A ) |
| DBSNP | rs2275558 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28270404}. |
| Mouse PG classification | NA |
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