| Gene Information | |
|---|---|
| Gene Name | ADAMTS17 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1095 |
| Protein Names | A disintegrin and metalloproteinase with thrombospondin motifs 17 (ADAM-TS 17) (ADAM-TS17) (ADAMTS-17) (EC 3.4.24.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000140470 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TE56 |
| Gene Card | ADAMTS17 |
| Uniprot ID | Q8TE56 |
| Pfam | PF17771; PF19236; PF05986; PF01562; PF01421; PF00090 |
| In ASD | no |
| Allosteric Prediction | no (-1.012972904) |
| Ortholog in Animals | Alpaca_ ADAMTS17 ( ortholog_one2one ) Dog_ ADAMTS17 ( ortholog_one2one ) GuineaPig_ ADAMTS17 ( ortholog_one2one ) Macaque_ ADAMTS17 ( ortholog_one2one ) Mouse_ Adamts17 ( ortholog_one2one ) Pig_ ADAMTS17 ( ortholog_one2one ) Rat_ Adamts17 ( ortholog_one2one ) Rabbit_ ADAMTS17 ( ortholog_one2one ) |
| Ohnologs | ADAMTS10, ADAMTS6, ADAMTS16, ADAMTS19, ADAMTS12 |
| Paralogs | ADAMTS5, ADAMTSL2, ADAMTS15, ADAMTS4, ADAMTS1, ADAMTS19, ADAMTS8, ADAMTSL3, ADAMTS7, THSD4, ADAMTSL4, ADAMTS3, ADAMTS20, ADAMTS6, ADAMTSL5, ADAMTS9, ADAMTS12, ADAMTS14, ADAMTS13, ADAMTSL1, ADAMTS10, ADAMTS16, PAPLN, ADAMTS2, ADAMTS18 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle. Isoform 1 and isoform 2 are expressed at high levels in the fetal heart, kidney, and whole eye, whereas a weak expression is seen in the fetal liver. {ECO:0000269|PubMed:19836009}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7496668 rs28567966 rs2573652 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Mouse PG classification | NA |
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