| Gene Information | |
|---|---|
| Gene Name | PAX8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 450 |
| Protein Names | Paired box protein Pax-8 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000125618 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q06710 |
| Gene Card | PAX8 |
| Uniprot ID | Q06710 |
| Pfam | PF00292; PF12403 |
| In ASD | no |
| Allosteric Prediction | yes (0.054517608) |
| Ortholog in Animals | Alpaca_ PAX8 ( ortholog_one2one ) Dog_ PAX8 ( ortholog_one2one ) GuineaPig_ PAX8 ( ortholog_one2one ) Macaque_ PAX8 ( ortholog_one2one ) Mouse_ Pax8 ( ortholog_one2one ) Rat_ Pax8 ( ortholog_one2one ) Rabbit_ PAX8 ( ortholog_one2one ) |
| Ohnologs | PAX2, PAX5 |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, PAX6, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | thyroid, kidney |
| Tissue Specificity | Expressed in the excretory system, thyroid gland and Wilms tumors. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2K27 (NMR - ) |
| DBSNP | rs104893657 rs104893656 rs104893659 rs104893658 rs3188996 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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