| Gene Information | |
|---|---|
| Gene Name | PAX6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 422 |
| Protein Names | Paired box protein Pax-6 (Aniridia type II protein) (Oculorhombin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000007372 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P26367 |
| Gene Card | PAX6 |
| Uniprot ID | P26367 |
| Pfam | PF00046; PF00292 |
| In ASD | no |
| Allosteric Prediction | no (-0.217903573) |
| Ortholog in Animals | Alpaca_ PAX6 ( ortholog_one2one ) Dog_ PAX6 ( ortholog_one2one ) GuineaPig_ PAX6 ( ortholog_one2one ) Macaque_ PAX6 ( ortholog_one2one ) Mouse_ Pax6 ( ortholog_one2one ) Pig_ PAX6 ( ortholog_one2one ) Rat_ Pax6 ( ortholog_one2one ) Rabbit_ PAX6 ( ortholog_one2one ) |
| Ohnologs | PAX4 |
| Paralogs | ARGFX, PAX7, PAX3, ALX4, PAX2, UNCX, RAX2, PAX8, DMBX1, DPRX, PAX5, ISX, ALX3, RHOXF2B, RHOXF2, GSC2, SEBOX, RAX, DRGX, ARX, RHOXF1, PITX3, PRRX1, SHOX, SHOX2, PRRX2, OTX2, PAX4, EVX1, PAX1, PITX2, PHOX2A, CRX, PHOX2B, EVX2, ALX1, VSX2, MIXL1, DUXA, OTP, HESX1, NOBOX, PROP1, PAX9, GSC, ESX1, DUXB, DUX4, PITX1, OTX1 |
| Tissue | brain, stomach, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | [Isoform 1]: Expressed in lymphoblasts. {ECO:0000269|PubMed:7958875}.; [Isoform 5a]: Weakly expressed in lymphoblasts. {ECO:0000269|PubMed:7958875}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CUE (NMR - ) 6PAX (X-ray 2.50A ) |
| DBSNP | rs121907913 rs121907920 rs121907923 rs121907928 rs121907919 rs121907918 rs749244084 rs757259413 rs121907927 rs121907925 rs373661718 rs200015827 rs1392343463 rs121907926 rs780356070 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:P63015}.; [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P63016}.; [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |