| Gene Information | |
|---|---|
| Gene Name | PAWR |
| Organism | Homo sapiens (Human) |
| Gene Length | 340 |
| Protein Names | PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) |
| Target Name | prostate apoptosis response-4 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000177425 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96IZ0 |
| Gene Card | PAWR |
| Uniprot ID | Q96IZ0 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.30667345) |
| Ortholog in Animals | Alpaca_ PAWR ( ortholog_one2one ) Dog_ PAWR ( ortholog_one2one ) GuineaPig_ PAWR ( ortholog_one2one ) Macaque_ PAWR ( ortholog_one2one ) Mouse_ Pawr ( ortholog_one2one ) Pig_ PAWR ( ortholog_one2one ) Rat_ Pawr ( ortholog_one2one ) Rabbit_ PAWR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. {ECO:0000269|PubMed:8943350}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JK9 (X-ray 1.79A ) |
| DBSNP | rs8176804 rs8176805 rs8176806 rs8176870 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. {ECO:0000250}. |
| Mouse PG classification | NA |
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