Gene Information
Gene NameDEGS1
OrganismHomo sapiens (Human)
Gene Length323
Protein NamesSphingolipid delta(4)-desaturase DES1 (EC 1.14.19.17) (Cell migration-inducing gene 15 protein) (Degenerative spermatocyte homolog 1) (Dihydroceramide desaturase-1) (Membrane lipid desaturase) (Retinol isomerase) (EC 5.2.1.-)
Target NameNA
Target TypeNA
Gene Age1714 ( ENSG00000143753 )
Evolutionary StageEukaryota
AlphaFoldDBO15121
Gene CardDEGS1
Uniprot IDO15121
PfamPF00487; PF08557
In ASDno
Allosteric Predictionno (-0.29350675)
Ortholog in AnimalsAlpaca_ DEGS1 ( ortholog_one2one )
Dog_ DEGS1 ( ortholog_one2one )
GuineaPig_ DEGS1 ( ortholog_one2one )
Macaque_ DEGS1 ( ortholog_one2one )
Mouse_ 9130409I23Rik ( ortholog_one2many )
Mouse_ Degs1 ( ortholog_one2many )
Pig_ DEGS1 ( ortholog_one2one )
Rat_ RGD1564463 ( ortholog_one2many )
Rat_ Degs1 ( ortholog_one2many )
OhnologsDEGS2
ParalogsDEGS2
TissueNA
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:9188692}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Mitochondrion membrane {ECO:0000269|PubMed:19647031, ECO:0000269|PubMed:30620338}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19647031, ECO:0000269|PubMed:30620338, ECO:0000269|PubMed:9188692};
Multi-pass membrane protein {ECO:0000269|PubMed:19647031, ECO:0000269|PubMed:9188692}.
Mouse PG classificationNA
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