| Gene Information | |
|---|---|
| Gene Name | PATJ |
| Organism | Homo sapiens (Human) |
| Gene Length | 1801 |
| Protein Names | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000132849 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8NI35 |
| Gene Card | PATJ |
| Uniprot ID | Q8NI35 |
| Pfam | PF09045; PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-0.373714044) |
| Ortholog in Animals | Alpaca_ PATJ ( ortholog_one2one ) Dog_ PATJ ( ortholog_one2one ) GuineaPig_ PATJ ( ortholog_one2one ) Macaque_ PATJ ( ortholog_one2one ) Mouse_ Patj ( ortholog_one2one ) Pig_ PATJ ( ortholog_one2one ) Rat_ Patj ( ortholog_one2one ) Rabbit_ PATJ ( ortholog_one2one ) |
| Ohnologs | MPDZ |
| Paralogs | FRMPD2, LNX1, LNX2, STXBP4, MPDZ |
| Tissue | NA |
| Tissue Specificity | Expressed in renal tubules (at protein level) (PubMed:19755384). Expressed in bladder, testis, ovary, small intestine, colon, heart, skeletal muscle, pancreas and cerebellum in the brain. {ECO:0000269|PubMed:11964389, ECO:0000269|PubMed:19755384, ECO:0000269|PubMed:9280290}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1VF6 (X-ray 2.10A ) 2D92 (NMR - ) 2DAZ (NMR - ) 2DB5 (NMR - ) 2DLU (NMR - ) 2DM8 (NMR - ) 2DMZ (NMR - ) 2EHR (NMR - ) 4Q2N (X-ray 2.00A ) 6IRD (X-ray 2.81A ) |
| DBSNP | rs3762321 rs1286823 rs7516332 rs1286812 rs1134764 rs12141598 rs12141599 rs2799627 rs1056513 rs1134767 rs2498982 rs13376115 |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:11964389, ECO:0000269|PubMed:12021270, ECO:0000269|PubMed:19755384, ECO:0000269|PubMed:22006950}. Apical cell membrane {ECO:0000269|PubMed:11964389}; Peripheral membrane protein {ECO:0000269|PubMed:11964389}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18596123}. Note=Localizes to the apical region at the start of epithelial cell polarization then locates to tight junctions as polarization is completed (PubMed:11964389). Localized in the paranodal region of myelinating Schwann cells (By similarity). Localized to the leading edge of the actin cortex of migrating epithelia cells (By similarity). {ECO:0000250|UniProtKB:E2QYC9, ECO:0000250|UniProtKB:Q63ZW7}. |
| Mouse PG classification | NA |
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