Gene Information
Gene NameTOP2A
OrganismHomo sapiens (Human)
Gene Length1531
Protein NamesDNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Target Namedna topoisomerase ii alpha
Target TypeClinical trial target
Gene Age645 ( ENSG00000131747 )
Evolutionary StageEukaryota
AlphaFoldDBP11388
Gene CardTOP2A
Uniprot IDP11388
PfamPF00204; PF00521; PF08070; PF02518; PF01751; PF16898
In ASDyes
Allosteric Predictionyes (0.956556232)
Ortholog in AnimalsAlpaca_ TOP2A ( ortholog_one2one )
Dog_ TOP2A ( ortholog_one2one )
GuineaPig_ TOP2A ( ortholog_one2one )
Macaque_ TOP2A ( ortholog_one2one )
Mouse_ Top2a ( ortholog_one2one )
Pig_ TOP2A ( ortholog_one2one )
Rat_ Top2a ( ortholog_one2one )
Rabbit_ TOP2A ( ortholog_one2one )
OhnologsNA
ParalogsTOP2B
Tissuebrain, testis
Tissue SpecificityExpressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056). {ECO:0000269|PubMed:9155056}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.010526(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZXM  (X-ray  1.87A  )  1ZXN  (X-ray  2.51A  )  4FM9  (X-ray  2.90A  )  4R1F  (X-ray  2.51A  )  5GWK  (X-ray  3.15A  )  5NNE  (X-ray  1.15A  )  6ZY5  (EM  3.60A  )  6ZY6  (EM  4.10A  )  6ZY7  (EM  4.64A  )  6ZY8  (EM  7.40A  ) 
DBSNP rs746765101  rs267607133  rs28969502  rs34300454  rs11540720 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:9155056}. Nucleus, nucleoplasm {ECO:0000269|PubMed:8299728}. Nucleus {ECO:0000269|PubMed:17567603, ECO:0000269|PubMed:22013166, ECO:0000269|PubMed:8299728, ECO:0000269|PubMed:9155056}. Nucleus, nucleolus {ECO:0000269|PubMed:9155056}.
Mouse PG classificationNA
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