| Gene Information | |
|---|---|
| Gene Name | PASK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1323 |
| Protein Names | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000115687 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96RG2 |
| Gene Card | PASK |
| Uniprot ID | Q96RG2 |
| Pfam | PF13426; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.221073377) |
| Ortholog in Animals | Alpaca_ PASK ( ortholog_one2one ) Dog_ PASK ( ortholog_one2one ) GuineaPig_ PASK ( ortholog_one2one ) Macaque_ PASK ( ortholog_one2one ) Mouse_ Pask ( ortholog_one2one ) Pig_ PASK ( ortholog_one2one ) Rat_ Pask ( ortholog_one2one ) Rabbit_ PASK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level). |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001759(Rat);0.015385(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1LL8 (NMR - ) 3DLS (X-ray 2.30A ) |
| DBSNP | rs1277219458 rs1470414 rs35187712 rs56033464 rs2240543 rs56372985 rs6727226 rs2005771 rs35129131 rs36082918 rs56139954 rs10167000 rs1131293 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17595531}. Nucleus {ECO:0000269|PubMed:17595531}. Note=Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails. |
| Mouse PG classification | NA |
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