Gene Information
Gene NamePRRT2
OrganismHomo sapiens (Human)
Gene Length340
Protein NamesProline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
Target NameNA
Target TypeNA
Gene Age454 ( ENSG00000167371 )
Evolutionary StageMammalia
AlphaFoldDBQ7Z6L0
Gene CardPRRT2
Uniprot IDQ7Z6L0
PfamPF04505
In ASDno
Allosteric Predictionno (-0.120907694)
Ortholog in AnimalsAlpaca_ PRRT2 ( ortholog_one2one )
Dog_ PRRT2 ( ortholog_one2one )
GuineaPig_ PRRT2 ( ortholog_one2one )
Macaque_ PRRT2 ( ortholog_one2one )
Mouse_ Prrt2 ( ortholog_one2one )
Pig_ PRRT2 ( ortholog_one2one )
Rat_ Prrt2 ( ortholog_one2one )
OhnologsNA
ParalogsPRRT1, PRRT1B, TRARG1, TMEM233
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs79182085  rs79568162  rs745594874  rs200926711  rs76335820  rs199556853  rs387907126  rs754897123  rs387907128  rs767799831  rs932713001  rs387907125 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:22101681, ECO:0000269|PubMed:25915028, ECO:0000269|PubMed:27172900};
Single-pass membrane protein {ECO:0000250|UniProtKB:E9PUL5}. Presynaptic cell membrane {ECO:0000250|UniProtKB:E9PUL5};
Single-pass membrane protein {ECO:0000250|UniProtKB:E9PUL5}. Synapse {ECO:0000250|UniProtKB:E9PUL5}. Cell projection, axon {ECO:0000269|PubMed:22832103}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D3ZFB6}. Postsynaptic density membrane {ECO:0000250|UniProtKB:D3ZFB6}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:D3ZFB6}.
Mouse PG classificationHPG
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