| Gene Information | |
|---|---|
| Gene Name | PARVA |
| Organism | Homo sapiens (Human) |
| Gene Length | 372 |
| Protein Names | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000197702 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NVD7 |
| Gene Card | PARVA |
| Uniprot ID | Q9NVD7 |
| Pfam | PF00307 |
| In ASD | no |
| Allosteric Prediction | no (-1.031853539) |
| Ortholog in Animals | Alpaca_ PARVA ( ortholog_one2one ) Dog_ PARVA ( ortholog_one2one ) GuineaPig_ PARVA ( ortholog_one2one ) Macaque_ PARVA ( ortholog_one2one ) Mouse_ Parva ( ortholog_one2one ) Pig_ PARVA ( ortholog_one2one ) Rat_ Parva ( ortholog_one2one ) Rabbit_ PARVA ( ortholog_one2one ) |
| Ohnologs | PARVB |
| Paralogs | PARVB, PARVG |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. {ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:11722847}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003212(Rat);0.031579(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K2R (NMR - ) 2VZC (X-ray 1.05A ) 2VZD (X-ray 2.10A ) 2VZG (X-ray 1.80A ) 2VZI (X-ray 2.20A ) 3KMU (X-ray 1.80A ) 3KMW (X-ray 2.00A ) 3REP (X-ray 1.80A ) 6MIB (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton. |
| Mouse PG classification | NA |
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