| Gene Information | |
|---|---|
| Gene Name | PARPL |
| Organism | Homo sapiens (Human) |
| Gene Length | 1724 |
| Protein Names | Protein mono-ADP-ribosyltransferase PARP4 (EC 2.4.2.-) (193 kDa vault protein) (ADP-ribosyltransferase diphtheria toxin-like 4) (ARTD4) (PARP-related/IalphaI-related H5/proline-rich) (PH5P) (Poly [ADP-ribose] polymerase 4) (PARP-4) (Vault poly(ADP-ribose) polymerase) (VPARP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UKK3 |
| Gene Card | PARP4 |
| Uniprot ID | Q9UKK3 |
| Pfam | PF00533; PF00644; PF08487; PF00092 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas. {ECO:0000269|PubMed:10477748}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35200240 rs9578751 rs9318600 rs4986818 rs7140044 rs2275660 rs34689435 rs9581043 rs4986822 rs1050110 rs13428 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10477748}. Nucleus {ECO:0000269|PubMed:10477748}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10477748}. Note=Also found in the nucleus, associated with mitotic spindles. {ECO:0000269|PubMed:10477748}. |
| Mouse PG classification | NA |
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