| Gene Information | |
|---|---|
| Gene Name | DCUN1D3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 304 |
| Protein Names | DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000188215 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IWE4 |
| Gene Card | DCUN1D3 |
| Uniprot ID | Q8IWE4 |
| Pfam | PF03556 |
| In ASD | no |
| Allosteric Prediction | no (-0.763112481) |
| Ortholog in Animals | Alpaca_ DCUN1D3 ( ortholog_one2one ) Dog_ DCUN1D3 ( ortholog_one2one ) Macaque_ DCUN1D3 ( ortholog_one2one ) Mouse_ Dcun1d3 ( ortholog_one2one ) Pig_ DCUN1D3 ( ortholog_one2one ) Rat_ Dcun1d3 ( ortholog_one2many ) Rabbit_ DCUN1D3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DCUN1D4, DCUN1D5, DCUN1D2, DCUN1D1 |
| Tissue | NA |
| Tissue Specificity | Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556). {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4GBA (X-ray 2.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19617556, ECO:0000269|PubMed:25349211, ECO:0000269|PubMed:26906416}. Cytoplasm {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:26906416}. Nucleus {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:26906416}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18823379}. Note=After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). {ECO:0000269|PubMed:18823379, ECO:0000269|PubMed:19617556}. |
| Mouse PG classification | NA |
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