| Gene Information | |
|---|---|
| Gene Name | ADK |
| Organism | Homo sapiens (Human) |
| Gene Length | 362 |
| Protein Names | Adenosine kinase (AK) (EC 2.7.1.20) (Adenosine 5'-phosphotransferase) |
| Target Name | adenosine kinase |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000156110 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55263 |
| Gene Card | ADK |
| Uniprot ID | P55263 |
| Pfam | PF00294 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000441669) |
| Ortholog in Animals | Alpaca_ ADK ( ortholog_one2one ) Dog_ ADK ( ortholog_one2one ) GuineaPig_ ADK ( ortholog_one2one ) Macaque_ ADK ( ortholog_one2one ) Mouse_ Adk ( ortholog_one2one ) Pig_ ADK ( ortholog_one2one ) Rat_ Adk ( ortholog_one2one ) Rabbit_ ADK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KHK, RBKS, TMEM256 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest level in placenta, liver, muscle and kidney. {ECO:0000269|PubMed:9070863}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BX4 (X-ray 1.50A ) 2I6A (X-ray 2.20A ) 2I6B (X-ray 2.30A ) 4O1L (X-ray 2.50A ) |
| DBSNP | rs397514454 rs397514453 rs397514452 |
| Subcellular location [CC] | [Isoform 1]: Nucleus {ECO:0000269|PubMed:19635462}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19635462}. |
| Mouse PG classification | NA |
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