| Gene Information | |
|---|---|
| Gene Name | PARD3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1205 |
| Protein Names | Partitioning defective 3 homolog B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein) (PAR3-beta) (Partitioning defective 3-like protein) (PAR3-L protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000116117 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TEW8 |
| Gene Card | PARD3B |
| Uniprot ID | Q8TEW8 |
| Pfam | PF12053; PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-0.945826592) |
| Ortholog in Animals | Alpaca_ PARD3B ( ortholog_one2one ) Dog_ PARD3B ( ortholog_one2one ) GuineaPig_ PARD3B ( ortholog_one2one ) Macaque_ PARD3B ( ortholog_one2one ) Mouse_ Pard3b ( ortholog_one2one ) Pig_ PARD3B ( ortholog_one2one ) Rat_ Pard3b ( ortholog_one2one ) Rabbit_ PARD3B ( ortholog_one2one ) |
| Ohnologs | PARD3 |
| Paralogs | PARD3 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.12(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1510765 rs2289025 rs1061522 rs34751010 |
| Subcellular location [CC] | Endomembrane system. Cell junction. Cell junction, tight junction. Note=Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions. |
| Mouse PG classification | NA |
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