| Gene Information | |
|---|---|
| Gene Name | PARD3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1356 |
| Protein Names | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000148498 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TEW0 |
| Gene Card | PARD3 |
| Uniprot ID | Q8TEW0 |
| Pfam | PF12053; PF00595 |
| In ASD | no |
| Allosteric Prediction | yes (0.734515808) |
| Ortholog in Animals | Alpaca_ PARD3 ( ortholog_one2one ) Dog_ PARD3 ( ortholog_one2one ) GuineaPig_ PARD3 ( ortholog_one2one ) Macaque_ PARD3 ( ortholog_one2one ) Mouse_ Pard3 ( ortholog_one2one ) Pig_ PARD3 ( ortholog_one2one ) Rat_ Pard3 ( ortholog_one2one ) Rabbit_ PARD3 ( ortholog_one2one ) |
| Ohnologs | PARD3B |
| Paralogs | PARD3B |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:12234671}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002061(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KOM (NMR - ) |
| DBSNP | rs1436731 rs199923448 rs3758459 rs1114167354 rs781461462 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Endomembrane system {ECO:0000269|PubMed:20332120}. Cell junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cell junction, tight junction {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q99NH2}. Cell membrane {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:27925688}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20332120}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheath (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}. |
| Mouse PG classification | NA |
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