| Gene Information | |
|---|---|
| Gene Name | LEPR |
| Organism | Homo sapiens (Human) |
| Gene Length | 131 |
| Protein Names | Leptin receptor gene-related protein (Endospanin-1) (Leptin receptor overlapping transcript protein) (OB-R gene-related protein) (OB-RGRP) |
| Target Name | leptin receptor |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000116678 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O15243 |
| Gene Card | LEPROT |
| Uniprot ID | O15243 |
| Pfam | PF04133 |
| In ASD | no |
| Allosteric Prediction | yes (0.50038583) |
| Ortholog in Animals | Alpaca_ LEPR ( ortholog_one2one ) Dog_ LEPR ( ortholog_one2one ) GuineaPig_ LEPR ( ortholog_one2one ) Macaque_ LEPR ( ortholog_one2one ) Mouse_ Lepr ( ortholog_one2one ) Pig_ LEPR ( ortholog_one2one ) Rat_ Lepr ( ortholog_one2one ) Rabbit_ LEPR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, GHR, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR |
| Tissue | dura.mater |
| Tissue Specificity | Expressed at the highest levels in heart and placenta and at a lesser extent in lung, liver, skeletal muscle, kidney and pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}. |
| Mouse PG classification | NA |
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