| Gene Information | |
|---|---|
| Gene Name | MACIR |
| Organism | Homo sapiens (Human) |
| Gene Length | 206 |
| Protein Names | Macrophage immunometabolism regulator |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000181751 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96GV9 |
| Gene Card | MACIR |
| Uniprot ID | Q96GV9 |
| Pfam | PF15435 |
| In ASD | no |
| Allosteric Prediction | no (-1.678030665) |
| Ortholog in Animals | Alpaca_ MACIR ( ortholog_one2one ) Dog_ MACIR ( ortholog_one2one ) GuineaPig_ MACIR ( ortholog_one2one ) Macaque_ MACIR ( ortholog_one2one ) Mouse_ Macir ( ortholog_one2one ) Pig_ MACIR ( ortholog_one2one ) Rat_ Macir ( ortholog_one2one ) Rabbit_ MACIR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | High expression in normal macrophages, monocytes, and cultured rheumatoid arthritis synovial fibroblasts (RASFs), with lower expression in B- and T-cells, and little to no expression in other tissues and cell lines. {ECO:0000269|PubMed:26316022}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:22085962, ECO:0000269|PubMed:30659109}. Cell projection, cilium {ECO:0000269|PubMed:22085962}. Note=Localizes to the transition zone and proximal cilium in addition to being found throughout the cytoplasm. {ECO:0000269|PubMed:22085962}. |
| Mouse PG classification | NA |
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