| Gene Information | |
|---|---|
| Gene Name | PAPPA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1791 |
| Protein Names | Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000116183 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BXP8 |
| Gene Card | PAPPA2 |
| Uniprot ID | Q9BXP8 |
| Pfam | PF00066; PF05572; PF00084 |
| In ASD | no |
| Allosteric Prediction | no (-1.123102212) |
| Ortholog in Animals | Alpaca_ PAPPA2 ( ortholog_one2one ) Dog_ PAPPA2 ( ortholog_one2one ) GuineaPig_ PAPPA2 ( ortholog_one2one ) Macaque_ PAPPA2 ( ortholog_one2one ) Mouse_ Pappa2 ( ortholog_one2one ) Pig_ PAPPA2 ( ortholog_one2one ) Rat_ Pappa2 ( ortholog_one2one ) Rabbit_ PAPPA2 ( ortholog_one2one ) |
| Ohnologs | PAPPA |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | placenta |
| Tissue Specificity | Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas. {ECO:0000269|PubMed:11264294, ECO:0000269|PubMed:11597188}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs36112782 rs34602579 |
| Subcellular location [CC] | Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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